Dawson MeDbz RAM Linker

Dawson MeDbz RAM linker on Polystyrene and TentaGel^® S: It is a new type of support for the synthesis of C-terminal peptide aryl thioesters by Fmoc SPPS. When peptide assembly is finished in a follow up reaction a cyclic N-acylurea is formed which can either be converted to the desired aryl thioester by aryl thiol or directly used in native chemical ligation without prior isolation of the intermediate precursor.

Figure 1: Dawson MeDbz RAM Linker on solid support.

Dawson MeDbz RAM Linker

Out now: Dawson MeDbz RAM linker on Polystyrene and TentaGel^® S.

It is a new type of support for the synthesis of C-terminal peptide aryl thioesters by Fmoc SPPS. When peptide assembly is finished in a follow up reaction a cyclic N-acylurea is formed which can either be converted to the desired aryl thioester by aryl thiol or directly used in native chemical ligation without prior isolation of the intermediate precursor.