ɑ-Alkynyl-ω-Iodoacetamido PEGs
This PEG crosslinking reagent with a terminal alkyne functionality on one chain end reacts with azides under "Click" Chemistry conditions (for example Cu(I) catalyzed alkyne-azide cycloaddition, CuAAC) to form a stable triazole link between the two reaction partners. The iodoacetamide group is known for its ability to react selectively with cysteine residues in proteins or other thiols, forming stable covalent bonds via thioether linkage.
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