ɑ-NHS-ω-Alkynyl PEGs
PEG butyric acid NHS derivatives have a C4 aliphatic chain directly attached to PEG and the NHS active ester is a useful reagent to pegylate proteines, peptides or any other surfaces with a free primary amino group to form stable amide bonds. This PEG crosslinking reagent with a terminal alkyne functionality on one chain end reacts with azides under "Click" Chemistry conditions (for example Cu(I) catalyzed alkyne-azide cycloaddition, CuAAC) to form a stable triazole link between the two reaction partners.
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