ɑ-Azido-ω-Trimethoxysilyl PEGs
This PEG crosslinking reagent with a terminal azide functionality at one chain end reacts with DBCO, BCN or other alkynes under "Click" Chemistry conditions (for example Cu(I) catalyzed alkyne-azide cycloaddition, CuAAC) to form a stable triazole link between the two reaction partners. The trimethoxysilyl functionality allows the pegylation of a variety of surfaces (e.g. glass, metals) and introduces PEG on hydroxylated surfaces in a one step procedure. Compared to Triethoxysilyl- the Trimethoxysilyl-PEG is more reactive.
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