ɑ-Biotinyl-ω-Pyridyldithio PEGs
PEG crosslinking agent for biotinylation. The biotinyl functionality is used to attach avidin or streptavidin containing substrates. Orthopyridyl disulfide (OPSS) PEGs are thiol-specific PEGylation reagents that react with free sulfhydryls (-SH) at a wide pH range (pH 3-10) through disulfide exchange. The newly formed disulfide (S-S) bond is unstable in a reducing environment. Thus, the bond can be cleaved to reverse the pegylation and release free thiols.
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