ɑ-Carboxy-ω-Boc-Amino PEGs
The butyric acid endgroup is directly connected to the PEG chain via a very stable ether linkage. After activation it is used to conjugate the PEG derivative to nucleophilic substrates, mainly amines (to form amides) or hydroxyls/thiols (forming esters). The Boc protecting group may be easily removed by (strong) acids such as TFA or at low pH in water to release the primary amine. Applicable for reversible or permanent crosslinking with PEG.
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