ɑ-Carboxy-ω-Mercapto PEGs
Carboxy PEGs may be used for conjugation to amine substrates (forming amides) or other nucleophiles (forming esters). The butyric acid endgroup is directly connected to the PEG chain via a very stable ether linkage. The free thiol groups react readily with maleimido or iodacetamido functionalities or transition metal surfaces like gold, silver etc. Reaction with other free thiols leads to S-S disulfide bonds which can be cleaved by reducing agents. PEG thiols may also be conjugated by thiol-ene chemistry.
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