ɑ-NHS-ω-Pyridyldithio PEGs
PEG butyric acid NHS derivatives have a C4 aliphatic chain directly attached to PEG and the NHS active ester is a useful reagent to pegylate proteines, peptides or any other surfaces with a free primary amino group to form stable amide bonds. Orthopyridyl disulfide (OPSS) PEGs are thiol-specific PEGylation reagents that react with free sulfhydryls (-SH) at a wide pH range (pH 3-10) through disulfide exchange. The newly formed disulfide (S-S) bond is unstable in a reducing environment. Thus, the bond can be cleaved to reverse the pegylation and release free thiols.
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