TentaGel® resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. TentaGel® resins have high diffusion rates and excellent swelling in a wide range of solvents from e.g. toluene to water. TentaGel® R resin is a special designed resin for research use. Long peptide sequences (up to 100 residues), difficult sequences and PNA´s are synthesized on this support.